CURRICULUM VITAE
James B. Bassingthwaighte

ADDRESS

Dept. of Bioengineering, Box 357962

University of Washington

Seattle, WA 98195-7962

TELEPHONES

206-685-2012, direct; 206-685-2005, secretary

BIRTHPLACE: Toronto, Canada

CITIZENSHIP: Canadian (U.S.)

EDUCATION

1951: B.A., University of Toronto. Fields: Physiology and Biochemistry

1955: M.D., University of Toronto

1957-1958: Postgraduate Medical School of London, England (Medicine)

1958-1961: Mayo Graduate School of Medicine, University of Minnesota (Medicine and Cardiology)

1964: Ph.D., Mayo Graduate School, University of Minnesota (Physiology)

CURRENT POSITIONS

Professor, Bioengineering, Biomathematics and Radiology, University of Washington, Seattle, WA

Director, National Simulation Resource Facility for Circulatory Mass Transport and Exchange, University of Washington

RESEARCH AND PROFESSIONAL EXPERIENCE

1955-1956: Intern, Toronto General Hospital

1956: Medical Clinic, International Nickel Company of Canada, Sudbury, Ontario

1957: General Practice, Matheson, Ontario

1957-1958: House Physician, Hammersmith Hospital, and Postgraduate Medical School of London

1958-1962: Resident in Medicine and Postdoctoral Fellowship in Physiology, Mayo Graduate School of Medicine, Rochester, Minnesota

1961-1962: Teaching Assistant, Dept. of Physiology, University of Minnesota

1962-1964: Assistant to the Staff, Physiology, Mayo Foundation

1964-1975: Consultant, Physiology, Mayo Graduate School of Medicine

1967-1969: Assistant Professor, Physiology, Mayo Graduate School of Medicine

1969-1972: Associate Professor, Physiology, Mayo Graduate School of Medicine

1970-1971: Visiting Professor, Pharmacology Institute, University of Bern, Switzerland

1972-1975: Associate Professor, Physiology and Medicine, Mayo Graduate School of Medicine

1973-1975: Professor, Physiology and Medicine, Mayo Graduate School of Medicine; Chair, Biophysics, Dept. of Physiology & Biophysics, Mayo Medical School

1975-1979: Director, Center for Bioengineering, University of Washington

1975-present: Professor, Bioengineering and Biomathematics, University of Washington

1980-1981: Visiting Professor, McGill University, Montreal, Quebec

Fall 1986: Visiting Professor, Physiology, Limburg University, Maastricht, Holland

1990-2000: Affiliate Professor, Physiology, Biophysics and Bioengineering, Univ. of Maastricht, Maastricht, Holland

1986-present: Professor, Radiology, University of Washington

1994: Visiting Professor, Department of Physiology, Free University Amsterdam

1996: Visiting Professor, Department of Physiology, Free University Amsterdam

1999: Visiting Professor, Physiology and Bioengineering, University of Maastricht

HONORS

1947-1951: Alumni Scholarship, University College, University of Toronto

1953: Undergraduate Scholarships, University of Toronto Medical School

1959-1962: Minnesota Heart Association Fellowship

1964: Mayo Alumni Balfour Award for Meritorious Research

1964-1974: NIH Research Career Development Award

1979: Louis and Artur Lucian Award, McGill University

1982: Witzig Award, Cardiovascular System Dynamics Society, Oxford

1986: Alza Award of the Biomedical Engineering Society

1986-1998: Chair, I.U.P.S. Commission Bioengineering in Physiology

1990: Lewellen-Thomas Lectureship, University of Toronto

1992-1993: Burlington Award for Outstanding Research in Engineering, University of Washington

1995: Landis Award (Microcirculatory Society)

1996: Oxford Lecturer, International Society for Magnetic Resonance in Medicine

1999: Distinguished Service Award, Biomedical Engineering Society

2000: Member, National Academy of Engineering

MAJOR RESEARCH INTERESTS

Cardiovascular physiology, transport of ions and substrates in the heart, myocardial blood flow, tracer kinetic modeling, cardiac myocyte and endothelial energetics and purine metabolism, fractal nature of physiological signals and anatomic structures.

SOCIETIES

1962-present: Sigma Xi
1972-1973: Mayo Foundation Chapter President

1965-present: American Heart Association
1966-present: Member, Councils on Circulation and Basic Science
1977-1979: Member of Executive Board, Council on Circulation
1980-1983: Research Committee

1965-present: American Physiological Society
1965: Fellow, Circulation Group (now Cardiovascular Section)
1979-1982: Education Committee
1989-2000: Technical Book Committee (Subcommittee of Publications); Chair, from 1991
1996-1997: Chair, Cardiovascular Section

1967-present: Microcirculatory Society, U.S.A.
1971-1974: Council Member
1979-1982: Liaison Committee
1989-1991: President-Elect and President
1991-1995: Publications Committee (Chair, 1993-5)
1990-1998: International Liaison Committee

1968-present: Biomedical Engineering Society
1971-1974: Member, Board of Directors
1977-1978: President
1978-1979: Chair, Nominating Committee
1978-1986: Representative, U.S.A. Nat'l Committee of Internat'l Union of Physiological Sciences
1980-1981: Chair, Awards Committee
1985-1989: Liaison Committee

1968-present: Biophysical Society

1984-present: Society for Mathematical Biology

COMMITTEES

1970-1974: Cardiovascular and Renal Study Section B, Division of Research Grants, National Institutes of Health (NIH)

1977-1979: Chair, Biotechnology Resources Advisory Committee, Division of Research Resources, National Institutes of Health (NIH)
1978-79: Chair, Subgroup on Bioengineering

1979-1983: Research Review Committee A, National Heart Lung & Blood Institute (NHLBI), NIH

1979-1986: National Academy of Sciences: U.S.A. National Committee for International Union of
Physiological Sciences.
1980-86: Vice Chair
1983-86: Chair

1980: Ad hoc member of Council, National Institute of General Medical Science, NIH

1983-1984: Member, Advisory Committee to the Director NIH, re: Division of Computer Research and Technology

1984-1986: Member, Engineering Research Board Panel on Bioengineering Systems Research, National Research Council, USA

1986-1998: Chair, Commission on Bioengineering in Physiology, International Union of Physiological Sciences

1987-1993: Advisory Committee to the Harvard-MIT Division of Health Sciences and Technology

1988-1991: Review Board, Canadian Centre of Excellence Program for Sciences, Arts, and Industry

1991-1995: Chair, Oversight Comm. for Respiratory Health Network Centre of Excellence (Canada)

1995-present: Whitaker Foundation Editorial Board of the Teaching Materials Program

1996-2000: Advisory Committee to the Department of Biomedical Engineering, Boston University

1997-1999: Member, International Assessment Comm. for Netherlands Biomedical Sciences Research (Royal Netherlands Academy of Arts and Sciences)

UNIVERSITY OF WASHINGTON COMMITTEES

1975: Biomathematics Group Committee

1975-1979: Graduate Faculty Group VII Committee

1975-1980: College of Engineering Executive Committee

1975-1980: School of Medicine Executive Committee

1978-1980: Faculty Senate Committee for Purchasing

1985-1987: Scientific Affairs Committee, School of Medicine

1989-1990: Review Committee on Quantitative Ecology and Resource Management

1990: Faculty Member, Quantitative Ecology and Resource Management

1991-present: Curriculum Committee, Department of Bioengineering

1992-1998: Human Biology Curriculum Committee, School of Medicine

EDITORIAL BOARDS

1972-1976: American Journal of Physiology

1977-1983: Microvascular Research

1979-1983: Biophysical Journal, Associate Editor

1980-1986: American Journal of Physiology

1981-present: International Journal of Microcirculation: Clinical and Experimental

1993-present: Editor-in-chief, Annals of Biomedical Engineering

1998-present: Journal of Vascular Research

1999-2002: American Journal of Physiology

Ad hoc reviewer for: Circulation Research, Science, Journal of General Physiology, Journal of Applied Physiology,

American Journal of Physiology, Microvascular Research, Nature, PNAS, Microcirculation, Physica D

ORGANIZATION OF INTERNATIONAL CONFERENCES

1975: Chair, U.S.-sponsored Symposium at International Congress of Microcirculation, Toronto

1976: Founding Chair, Gordon Research Conf., "Water and Solute Transport in the Microvasculature"

1979: Chair, Workshop on Simulation in the Life Sciences, DRR, NIH, Seattle, WA

1982: Chair, Conference on Endothelial Surface Reaction and Exchange Processes, Seattle, WA

1983-1986: International Union of Physiological Sciences, Program Committee for 1986 Congress

1984: Chair, Workshop on Cardiovascular Metabolic Imaging, NHLBI, NIH, Bethesda, MD

1984-1997: Organizing Committee, Henry Goldberg Annual Workshops on Simulation and Control in the Cardiovascular Systems (held in Israel, England, USA)

1986: Chair, IUPS Satellite Meeting, Endothelial Transport and Metabolism, Seattle, WA

1987-present: Chair, Workshops on Exchange Processes in Biological Systems (held in Seattle each August under the auspices of the Simulation Resource Facility)

1988: Chair, Symposia on Fractals in Physiology and Medicine at World Congress on Medical Physics and Bioengineering, San Antonio

1989: Co-Chair, IUPS Satellite Symposium on Microvascular Networks (July 16-19, Berlin)

1990: Chair, Pre-FASEB Symposium on Microcirculatory Exchange Processes, Washington, D.C.

1990-1991: Program Committee, World Congress for Microcirculation (Aug. 31-Sept. 5, 1991)

1995: Organizer and Chair of conference "The Whole Organ Approach to Cellular Metabolism: Capillary Permeation, Cellular Uptake, and Product Formation", Montreal, Canada (July 1995)

1996: Chair, Symposia on Chaotic, Fractal and Self-Organizing systems, World Congress for Microcirculation, Munich

1997: Organizer and Chair, IUPS satellite conference "On Designing the Physiome Project", St. Petersburg, Russia (July 1997)

PUBLICATIONS (Classified as Books, Refereed Papers, and Refereed Book Chapters)

Books and Special Issues:

McMillin-Wood, J. B., and J. B. Bassingthwaighte, Editors. Cardiovascular Metabolic Imaging: Physiological and Biochemical Dynamics In Vivo . Circulation 72 (Suppl):IV1-IV171, 1985.

Bassingthwaighte, J. B., L. S. Liebovitch, and B. J. West. Fractal Physiology . New York, London: Oxford University Press, 1994, 364 pp.

Bassingthwaighte, J. B., C. A. Goresky, and J. H. Linehan, Editors. Whole organ approaches to cellular metabolism. Capillary permeation, cellular uptake and product formation. . New York: Springer Verlag, 1998, 575 pp.

McCulloch, A., J. B. Bassingthwaighte, P. Hunter, and D. Noble. Computational Biology of the Heart: From Structure to Function. Progress in Biophysics and Molecular Biology Volume 69, 151-572 : Elsevier/Pergamon, 1998.

Refereed Papers:

Bassingthwaighte, J. B. Plasma volume expanders in burn shock. University of Toronto Med. J. 30:239-247, 1953.

Edwards, A. W. T., J. B. Bassingthwaighte, W. F. Sutterer, and E. H. Wood. Blood level of indocyanine green in the dog during multiple dye curves and its effect on instrumental calibration. Proc. S. M. Mayo Clin. 35:747-751, 1960.

Bassingthwaighte, J. B., A. W. T. Edwards, and E. H. Wood. Areas of dye-dilution curves sampled simultaneously from central and peripheral sites. J. Appl. Physiol. 17:91-98, 1962.

Bassingthwaighte, J. B., T. W. Parkin, J. W. DuShane, E. H. Wood, and H. B. Burchell. The electrocardiographic and hemodynamic findings in pulmonary stenosis with intact ventricular septum. Circulation 28:893-905, 1963.

Edwards, A. W. T., J. Isaacson, W. F. Sutterer, J. B. Bassingthwaighte, and E. H. Wood. Indocyanine green densitometry in flowing blood compensated for background dye. J. Appl. Physiol. 18:1294-1304, 1963.

Bassingthwaighte, J. B., A. W. T. Edwards, and E. H. Wood. Use of an optical density ruler in measurements of dye-dilution curves. J. Appl. Physiol. 19:347-353, 1964.

Bassingthwaighte, J. B., and H. R. Warner. Indicator dispersion in the circulation. Am. Heart J. 69:838-841, 1965.

Bassingthwaighte, J. B., F. H. Ackerman, and E. H. Wood. Applications of the lagged normal density curve as a model for arterial dilution curves. Circ. Res. 18:398-415, 1966.

Bassingthwaighte, J. B., H. R. Warner, and E. H. Wood. Analog computer analysis of dispersion of indicator in the circulation. Med. Res. Eng. 5:30-37x47, 1966.

Bassingthwaighte, J. B. Plasma indicator dispersion in arteries of the human leg. Circ. Res. 19:332-346, 1966.

Coulam, C. M., H. R. Warner, E. H. Wood, and J. B. Bassingthwaighte. A transfer function analysis of coronary and renal circulation calculated from upstream and downstream indicator-dilution curves. Circ. Res. 19:879-890, 1966.

Bassingthwaighte, J. B. Circulatory transport and the convolution integral. Mayo Clin. Proc. 42:137-154, 1967.

Bassingthwaighte, J. B., and F. H. Ackerman. Mathematical linearity of circulatory transport. J. Appl. Physiol. 22:879-888, 1967.

Coulam, C. M., H. R. Warner, H. W. Marshall, and J. B. Bassingthwaighte. A steady-state transfer function analysis of portions of the circulatory system using indicator dilution techniques. Comput. Biomed. Res. 1:124-138, 1967.

Bassingthwaighte, J. B., T. Strandell, and D. E. Donald. Estimation of coronary blood flow by washout of diffusible indicators. Circ. Res. 23:259-278, 1968.

Harvey, R. B., J. B. Bassingthwaighte, and R. L. Heppner. Regulation of plasma creatinine concentration by use of a servo control system. Clin. Chem. 14:944-959, 1968.

Knopp, T. J., and J. B. Bassingthwaighte. Effect of flow on transpulmonary circulatory transport functions. J. Appl. Physiol. 27:36-43, 1969.

Richmond, D. R., W. N. Tauxe, and J. B. Bassingthwaighte. Albumin macroaggregates and measurements of regional blood flow: Validity and application of particle sizing by Coulter counter. J. Lab. Clin. Med. 75:336-346, 1970.

Knopp, T. J., D. U. Anderson, and J. B. Bassingthwaighte. SIMCON--Simulation control to optimize man-machine interaction. Simulation 14:81-86, 1970.

Bassingthwaighte, J. B. Blood flow and diffusion through mammalian organs. Science 167:1347-1353, 1970.

Riggs, B. L., Jr., J. B. Bassingthwaighte, J. Jowsey, and E. P. Pequegnat. Autoradiographic method for quantitation of deposition and distribution of radiocalcium in bone. J. Lab. Clin. Med. 75:520-528, 1970.

Bassingthwaighte, J. B., R. E. Sturm, and E. H. Wood. Advances in indicator dilution techniques applicable to studies of the acutely ill patient. Mayo Clin. Proc. 45:563-572, 1970.

Bassingthwaighte, J. B., T. J. Knopp, and D. U. Anderson. Flow estimation by indicator dilution (bolus injection): Reduction of errors due to time-averaged sampling during unsteady flow. Circ. Res. 27:277-291, 1970.

Yipintsoi, T., and J. B. Bassingthwaighte. Circulatory transport of iodoantipyrine and water in the isolated dog heart. Circ. Res. 27:461-477, 1970.

Spangler, R. D., T. Yipintsoi, T. J. Knopp, R. L. Frye, and J. B. Bassingthwaighte. Pulmonary mean-transit-time blood volumes in anesthetized dogs. J. Appl. Physiol. 30:56-63, 1971.

Yipintsoi, T., D. C. Gustafson, and J. B. Bassingthwaighte. Separation of unbound iodide in $125i$-labeled antipyrine. J. Nucl. Med. 12:149-152, 1971.

Kelly, P. J., T. Yipintsoi, and J. B. Bassingthwaighte. Blood flow in canine tibial diaphysis estimated by iodoantipyrine-$125i$ washout. J. Appl. Physiol. 31:38-47, 1971.

Riggs, B. L., J. H. Marshall, J. Jowsey, R. P. Heaney, and J. B. Bassingthwaighte. Quantitative $nots 45$Ca autoradiography of human bone. J. Lab. Clin. Med. 78:585-598, 1971.

Heppner, R. L., R. B. Harvey, and J. B. Bassingthwaighte. Creatinine distribution dynamics in the dog. J. Appl. Physiol. 32:495-500, 1972.

Bassingthwaighte, J. B., and H. B. Burchell. Duration of cardiac systole in children with femoral arteriovenous fistulas. Am. Heart J. 83:732-742, 1972.

Knopp, T. J., D. U. Anderson, and J. B. Bassingthwaighte. A computer interface for radioisotope data processing. Comput. Biomed. Res. 5:479-483, 1972.

Yipintsoi, T., P. D. Scanlon, and J. B. Bassingthwaighte. Density and water content of dog ventricular myocardium. Proc. Soc. Exp. Biol. Med. 141:1032-1035, 1972.

Richmond, D. R., T. Yipintsoi, C. M. Coulam, J. L. Titus, and J. B. Bassingthwaighte. Macroaggregated albumin studies of the coronary circulation in the dog. J. Nucl. Med. 14:129-134, 1973.

Yipintsoi, T., W. A. Dobbs, Jr., P. D. Scanlon, T. J. Knopp, and J. B. Bassingthwaighte. Regional distribution of diffusible tracers and carbonized microspheres in the left ventricle of isolated dog hearts. Circ. Res. 33:573-587, 1973.

Paradis, G. R., J. B. Bassingthwaighte, and P. J. Kelly. Inhibition of transport of $47ca$ and $85sr$ by lanthanum in canine cortical bone. J. Appl. Physiol. 36:221-225, 1974.

Bassingthwaighte, J. B., T. Yipintsoi, and R. B. Harvey. Microvasculature of the dog left ventricular myocardium. Microvasc. Res. 7:229-249, 1974.

Bassingthwaighte, J. B., and T. Yipintsoi. Organ blood flow, wash-in, wash-out, and clearance of nutrients and metabolites. Mayo Clin. Proc. 49:248-255, 1974.

Bassingthwaighte, J. B. A concurrent flow model for extraction during transcapillary passage. Circ. Res. 35:483-503, 1974.

Suenson, M., D. R. Richmond, and J. B. Bassingthwaighte. Diffusion of sucrose, sodium, and water in ventricular myocardium. Am. J. Physiol. 227:1116-1123, 1974.

Cofield, R. H., J. B. Bassingthwaighte, and P. J. Kelly. Strontium 85 extraction and clearance and bone blood flow. Surgical Forum 25:481-483, 1974.

Bassingthwaighte, J. B., T. Yipintsoi, and E. F. Grabowski. Myocardial capillary permeability: Hydrophilic solutes penetrate 100 Å intercellular clefts. Bibl. Anat. 13:24-27, 1975.

Guller, B., T. Yipintsoi, A. L. Orvis, and J. B. Bassingthwaighte. Myocardial sodium extraction at varied coronary flows in the dog: Estimation of capillary permeability by residue and outflow detection. Circ. Res. 37:359-378, 1975.

Sidell, P. M., D. U. Anderson, T. J. Knopp, and J. B. Bassingthwaighte. Computer graphics in simulation of cardiovascular transport phenomena. Computers and Graphics 1:289-292, 1975.

Tancredi, R. G., T. Yipintsoi, and J. B. Bassingthwaighte. Capillary and cell wall permeability to potassium in isolated dog hearts. Am. J. Physiol. 229:537-544, 1975.

Cofield, R. H., J. B. Bassingthwaighte, and P. J. Kelly. Strontium-85 extraction during transcapillary passage in tibial bone. J. Appl. Physiol. 39:596-602, 1975.

Davies, D. R., J. B. Bassingthwaighte, and P. J. Kelly. Transcapillary exchange of strontium and sucrose in canine tibia. J. Appl. Physiol. 40:17-22, 1976.

Knopp, T. J., W. A. Dobbs, J. F. Greenleaf, and J. B. Bassingthwaighte. Transcoronary intravascular transport functions obtained via a stable deconvolution technique. Ann. Biomed. Eng. 4:44-59, 1976.

Lightfoot, E. N., J. B. Bassingthwaighte, and E. F. Grabowski. Hydrodynamic models for diffusion in microporous membranes. Ann. Biomed. Eng. 4:78-90, 1976.

Bassingthwaighte, J. B., and G. A. Holloway, Jr.. Estimation of blood flow with radioactive tracers. Semin. Nucl. Med. 6:141-161, 1976.

Bassingthwaighte, J. B., C. H. Fry, and J. A. S. McGuigan. Relationship between internal calcium and outward current in mammalian ventricular muscle; A mechanism for the control of the action potential duration?. J. Physiol. 262:15-37, 1976.

Bassingthwaighte, J. B. Relative dispersion: A characterizing feature of specific vascular beds. Anesth. Analg. 56:72-77, 1977.

Hughes, S. P. F., D. R. Davies, J. B. Bassingthwaighte, F. G. Knox, and P. J. Kelly. Bone extraction and blood clearance of diphosphonate in the dog. Am. J. Physiol. 232 ( Heart Circ. Physiol. 1):H341-H347, 1977.

Safford, R. E., and J. B. Bassingthwaighte. Calcium diffusion in transient and steady states in muscle. Biophys. J. 20:113-136, 1977.

Bassingthwaighte, J. B. Physiology and theory of tracer washout techniques for the estimation of myocardial blood flow: Flow estimation from tracer washout. Prog. Cardiovasc. Dis. 20:165-189, 1977.

Kelly, P. J., and J. B. Bassingthwaighte. Studies on bone ion exchanges using multiple-tracer indicator-dilution techniques. Fed. Proc. 36:2634-2639, 1977.

Bassingthwaighte, J. B., R. King, E. Bouskela, D. Williams, and G. A. Holloway, Jr.. Transcoronary intravascular transport functions in dog hearts. Bibl. Anat. 15:48-52, 1977.

Safford, R. E., E. A. Bassingthwaighte, and J. B. Bassingthwaighte. Diffusion of water in cat ventricular myocardium. J. Gen. Physiol. 72:513-538, 1978.

Kuikka, J., E. Bouskela, and J. Bassingthwaighte. D-, L-, and 2-deoxy-D-glucose uptakes in the isolated blood perfused dog hearts. Bibl. Anat. 18:239-242, 1979.

Hughes, S. P. F., G. J. Lemon, D. R. Davies, J. B. Bassingthwaighte, and P. J. Kelly. Extraction of minerals after experimental fractures of the tibia in dogs. J. Bone Joint Surg. 61-A:857-866, 1979.

Levin, M., J. Kuikka, and J. B. Bassingthwaighte. Sensitivity analysis in optimization of time-distributed parameters for a coronary circulation model. Med. Prog. Technol. 7:119-124, 1980.

Lemon, G. J., D. R. Davies, S. P. F. Hughes, J. B. Bassingthwaighte, and P. J. Kelly. Transcapillary exchange and retention of fluoride, strontium, EDTA, sucrose, and antipyrine in bone. Calcif. Tissue Int. 31:173-181, 1980.

Lopez-Curto, J. A., J. B. Bassingthwaighte, and P. J. Kelly. Anatomy of the microvasculature of the tibial diaphysis of the adult dog. J. Bone Joint Surg. 62-A:1362-1369, 1980.

Wong, A. Y. K., and J. B. Bassingthwaighte. The kinetics of Ca-Na exchange in excitable tissue. Math Bioscience 52:275-310, 1981.

Bassingthwaighte, J. B., M. Levin, and F. Gonzalez. On the estimation of rates of capillary-to-cell exchange of substrates and ions. Bibl. Anat. 20:493-496, 1981.

Winkler, B., J. B. Bassingthwaighte, and W. Schaper. Permeation of cations through myocytes determined by the multiple indicator technique. Bibl. Anat. 20:525-528, 1981.

Bassingthwaighte, J. B., and M. Levin. Analysis of coronary outflow dilution curves for the estimation of cellular uptake rates in the presence of heterogeneous regional flows. Basic Res. Cardiol. 76:404-410, 1981.

Lemon, G. J., J. B. Bassingthwaighte, and P. J. Kelly. Influence of parathyroid state on calcium uptake in bone. Am. J. Physiol. 242 ( Endocrinol. Metab. 5):E146-E153, 1982.

Bridge, J. H. B., M. M. Bersohn, F. Gonzalez, and J. B. Bassingthwaighte. Synthesis and use of radiocobaltic EDTA as an extracellular marker in rabbit heart. Am. J. Physiol. 242 ( Heart Circ. Physiol. 11):H671-H676, 1982.

Maltby, B., G. J. Lemon, J. B. Bassingthwaighte, and P. J. Kelly. Exchange of potassium and strontium in adult bone. Am. J. Physiol. 242 ( Heart Circ. Physiol. 11):H705-H712, 1982.

Morris, M. A., J. A. Lopez-Curto, S. P. F. Hughes, K. An, J. B. Bassingthwaighte, and P. J. Kelly. Fluid spaces in canine bone and marrow. Microvasc. Res. 23:188-200, 1982.

Bassingthwaighte, J. B. Overview of symposium: Measuring cellular transport in vivo . Fed. Proc. 41:3031-3032, 1982.

Bassingthwaighte, J. B. Cellular influx and efflux in the heart. Fed. Proc. 41:3040-3044, 1982.

Bridge, J. H. B., and J. B. Bassingthwaighte. Uphill sodium transport driven by an inward calcium gradient in heart muscle. Science 219:178-180, 1983.

Little, S. E., and J. B. Bassingthwaighte. Plasma-soluble marker for intraorgan regional flows. Am. J. Physiol. 245 ( Heart Circ. Physiol. 14):H707-H712, 1983.

Bassingthwaighte, J. B., and M. Chaloupka. Sensitivity functions in the estimation of parameters of cellular exchange. Fed. Proc. 43:180-184, 1984.

Bassingthwaighte, J. B., T. Yipintsoi, and T. J. Knopp. Diffusional arteriovenous shunting in the heart. Microvasc. Res. 28:233-253, 1984.

Bassingthwaighte, J. B., J. B. McMillin-Wood, T. R. Brown, T. F. Budinger, J. S. Ingwall, M. J. Rovetto, H. R. Schelbert, and Z. McCallum. Cardiovascular Metabolic Imaging: Physiologic and Biochemical Dynamics in vivo : Report of a workshop held in Bethesda, Maryland, Sept. 16-18, 1984. Circulation 72:IV151-IV171, 1985.

Sparks, H. V., Jr., D. F. DeWitt, R. D. Wangler, M. W. Gorman, and J. B. Bassingthwaighte. Capillary transport of adenosine. Fed. Proc. 44:2620-2622, 1985.

Bassingthwaighte, J. B., H. V. Sparks, Jr., I. S. Chan, D. F. DeWitt, and M. W. Gorman. Modeling of transendothelial transport. Fed. Proc. 44:2623-2626, 1985.

Bassingthwaighte, J. B., J. T. Kuikka, I. S. Chan, T. Arts, and R. S. Reneman. A comparison of ascorbate and glucose transport in the heart. Am. J. Physiol. 249 ( Heart Circ. Physiol. 18):H141-H149, 1985.

Arts, T., J. T. Kuikka, R. S. Reneman, and J. B. Bassingthwaighte. Polarographic measurement of ascorbate washout in isolated perfused rabbit hearts. Am. J. Physiol. 249 ( Heart Circ. Physiol. 18):H150-H154, 1985.

King, R. B., J. B. Bassingthwaighte, J. R. S. Hales, and L. B. Rowell. Stability of heterogeneity of myocardial blood flow in normal awake baboons. Circ. Res. 57:285-295, 1985.

Bassingthwaighte, J. B. Overview of the processes of delivery: flow, transmembrane transport, reaction and retention. In: Cardiovascular Metabolic Imaging: Physiological and Biochemical Dynamics in vivo , edited by J. B. McMillin-Wood and J. B. Bassingthwaighte. Circulation 72 Suppl. IV, 1985, pp. 39-46.

Kuikka, J., M. Levin, and J. B. Bassingthwaighte. Multiple tracer dilution estimates of D- and 2-deoxy-D-glucose uptake by the heart. Am. J. Physiol. 250 ( Heart Circ. Physiol. 19):H29-H42, 1986.

Gorman, M. W., J. B. Bassingthwaighte, R. A. Olsson, and H. V. Sparks. Endothelial cell uptake of adenosine in canine skeletal muscle. Am. J. Physiol. 250 ( Heart Circ. Physiol. 19):H482-H489, 1986.

Bassingthwaighte, J. B., and H. V. Sparks. Indicator dilution estimation of capillary endothelial transport. Annu. Rev. Physiol. 48:321-334, 1986.

Bassingthwaighte, J. B., F. P. Chinard, C. Crone, C. A. Goresky, N. A. Lassen, R. S. Reneman, and K. L. Zierler. Terminology for mass transport and exchange. Am. J. Physiol. 250 ( Heart Circ. Physiol. 19):H539-H545, 1986.

Little, S. E., J. M. Link, K. A. Krohn, and J. B. Bassingthwaighte. Myocardial extraction and retention of 2-iododesmethylimipramine: a novel flow marker. Am. J. Physiol. 250 ( Heart Circ. Physiol. 19):H1060-H1070, 1986.

Bassingthwaighte, J. B. Strides in the technology of systems physiology and the art of testing complex hypotheses. Fed. Proc. 46:2473-2476, 1987.

Bassingthwaighte, J. B. Through the microcirculatory maze with machete, molecule, and minicomputer (1986 Alza Lecture). Ann. Biomed. Eng. 15:503-519, 1987.

Bassingthwaighte, J. B., M. A. Malone, T. C. Moffett, R. B. King, S. E. Little, J. M. Link, and K. A. Krohn. Validity of microsphere depositions for regional myocardial flows. Am. J. Physiol. 253 ( Heart Circ. Physiol. 22):H184-H193, 1987.

Bassingthwaighte, J. B. Physiological heterogeneity: Fractals link determinism and randomness in structures and functions. News Physiol. Sci. 3:5-10, 1988.

Moffett, T. C., I. S. Chan, and J. B. Bassingthwaighte. Myocardial serotonin exchange: negligible uptake by capillary endothelium. Am. J. Physiol. 254 ( Heart Circ. Physiol. 23):H570-H577, 1988.

Bassingthwaighte, J. B., I. S. Chan, and A. A. Goldstein. An efficient method for smoothing indicator-dilution and other unimodal curves. Comput. Biomed. Res. 21:192-202, 1988.

Bassingthwaighte, J. B., I. S. Chan, A. A. Goldstein, and I. B. Russak. GGOPT- an unconstrained non-linear optimizer. Comput. Meth. Prog. Biomed. 26:275-281, 1988.

Axelsen, P. H., and J. B. Bassingthwaighte. A constraint on possible stoichiometries of myocardial sodium-calcium exchange. Basic. Res. Cardiol. 83:314-326, 1988.

Bassingthwaighte, J. B., and J. H. G. M. van Beek. Lightning and the heart: Fractal behavior in cardiac function. Proc. IEEE 76:693-699, 1988.

King, R. B., and J. B. Bassingthwaighte. Temporal fluctuations in regional myocardial flows. Pflügers Arch.(Eur.J.Physiol.) 413/4:336-342, 1989.

Wangler, R. D., M. W. Gorman, C. Y. Wang, D. F. DeWitt, I. S. Chan, J. B. Bassingthwaighte, and H. V. Sparks. Transcapillary adenosine transport and interstitial adenosine concentration in guinea pig hearts. Am. J. Physiol. 257 ( Heart Circ. Physiol. 26):H89-H106, 1989.

Bassingthwaighte, J. B., L. Noodleman, G. J. van der Vusse, and J. F. C. Glatz. Modeling of palmitate transport in the heart. Mol. Cell Biochem. 88:51-58, 1989.

Bassingthwaighte, J. B., R. B. King, and S. A. Roger. Fractal nature of regional myocardial blood flow heterogeneity. Circ. Res. 65:578-590, 1989.

Bassingthwaighte, J. B., C. Y. Wang, and I. S. Chan. Blood-tissue exchange via transport and transformation by endothelial cells. Circ. Res. 65:997-1020, 1989.

van Beek, J. H. G. M., S. A. Roger, and J. B. Bassingthwaighte. Regional myocardial flow heterogeneity explained with fractal networks. Am. J. Physiol. 257 ( Heart Circ. Physiol. 26):H1670-H1680, 1989.

Gonzalez, F., and J. B. Bassingthwaighte. Heterogeneities in regional volumes of distribution and flows in the rabbit heart. Am. J. Physiol. 258 ( Heart Circ. Physiol. 27):H1012-H1024, 1990.

Bassingthwaighte, J. B., M. A. Malone, T. C. Moffett, R. B. King, I. S. Chan, J. M. Link, and K. A. Krohn. Molecular and particulate depositions for regional myocardial flows in sheep. Circ. Res. 66:1328-1344, 1990.

King, R. B., L. J. Weissman, and J. B. Bassingthwaighte. Fractal descriptions for spatial statistics. Ann. Biomed. Eng. 18:111-121, 1990.

Caldwell, J. H., G. V. Martin, J. M. Link, M. Gronka, K. A. Krohn, and J. B. Bassingthwaighte. Iodophenylpentadecanoic acid - myocardial blood flow relationship during maximal exercise with coronary occlusion. J. Nucl. Med. 30:99-105, 1990.

Wang, C. Y., and J. B. Bassingthwaighte. Area-filling distributive network model. Mathl. Comput. Modelling 13:27-33, 1990.

Glenny, R., H. T. Robertson, S. Yamashiro, and J. B. Bassingthwaighte. Applications of fractal analysis to physiology. J. Appl. Physiol. 70:2351-2367, 1991.

Kuikka, J. T., J. B. Bassingthwaighte, M. M. Henrich, and L. E. Feinendegen. Mathematical modeling in nuclear medicine. Eur. J. Nucl. Med. 18:351-362, 1991.

Bassingthwaighte, J. B., and R. P. Beyer. Fractal correlation in heterogeneous systems. Physica D 53:71-84, 1991.

Gorman, M. W., R. D. Wangler, J. B. Bassingthwaighte, D. E. Mohrman, C. Y. Wang, and H. V. Sparks. Interstitial adenosine concentration during norepinephrine infusion in isolated guinea pig hearts. Am. J. Physiol. (Heart.Circ.Physiol.30) 261:H901-909, 1991.

Bassingthwaighte, J. B. A commentary on "The microcirculation of myocutaneous island flaps in pigs studied with radioactive blood volume tracers and microspheres of different sizes", V. E. Hjortdal, E. S. Hansen, T. B. Henriksen, D. Kjolseth, K. Soballe, J. C. Djurhuus. Plastic and Reconstructive Surgery 89:123-124, 1991.

Wong, A. Y. K., A. Fabiato, and J. B. Bassingthwaighte. Model of calcium-induced calcium release mechanism in cardiac cells. Bull. Math. Biol. 54:95-116, 1992.

Kroll, K., T. R. Bukowski, L. M. Schwartz, D. Knoepfler, and J. B. Bassingthwaighte. Capillary endothelial transport of uric acid in the guinea pig heart. Am. J. Physiol. (Heart Circ. Physiol. 31) 262:H420-H431, 1992.

Wang, C. Y., L. J. Weissman, and J. B. Bassingthwaighte. Bifurcating distributive system using Monte Carlo method. Mathl. Comput. Modelling 16:91-98, 1992.

Schepers, H. E., J. H. G. M. van Beek, and J. B. Bassingthwaighte. Comparison of four methods to estimate the fractal dimension from self-affine signals. IEEE Eng. Med. Biol. 11:57-64x71, 1992.

Shields, A. F., M. M. Graham, S. M. Kozawa, L. B. Kozell, J. M. Link, E. R. Swenson, A. M. Spence, J. B. Bassingthwaighte, and K. A. Krohn. Contribution of labeled carbon dioxide to PET imaging of carbon-11-labeled compounds. J. Nucl. Med. 33:581-584, 1992.

Bassingthwaighte, J. B. Fractal vascular growth patterns. Acta Stereol. 11 (Suppl. 1):305-319, 1992.

Bassingthwaighte, J. B. Interstitial adenosine: the measurement, the interpretation. J. Mol. Cell. Cardiol. 24:337-346, 1992.

Bukowski, T., T. C. Moffett, J. H. Revkin, J. D. Ploger, and J. B. Bassingthwaighte. Triple-label $beta$ liquid scintillation counting. Anal. Biochem. 204:171-180, 1992.

Bassingthwaighte, J. B., I. S. Chan, and C. Y. Wang. Computationally efficient algorithms for capillary convection-permeation-diffusion models for blood-tissue exchange. Ann. Biomed. Eng. 20:687-725, 1992.

Slaaf, D. W., S. M. Yamashiro, G. J. Tangelder, R. S. Reneman, and J. B. Bassingthwaighte. Nonlinear dynamics of vasomotion. In: Vasomotion and Flowmotion. Prog. Appl. Microcirc.Vol. 20: , edited by C. Allegra, M. Intaglietta and K. Messmer, 1993, pp. 67-80.

King, R. B., A. Deussen, G. R. Raymond, and J. B. Bassingthwaighte. A vascular transport operator. Am. J. Physiol. 265 ( Heart Circ. Physiol. 34):H2196-H2208, 1993.

Chan, I. S., A. A. Goldstein, and J. B. Bassingthwaighte. SENSOP: A derivative-free solver for non-linear least squares with sensitivity scaling. Ann. Biomed. Eng. 21:621-631, 1993.

Wilke, N., M. Jerosch-Herold, A. E. Stillman, K. Kroll, N. Tsekos, H. Merkle, T. Parrish, X. Hu, Y. Wang, J. Bassingthwaighte, R. J. Bache, and K. Ugurbil. Concepts of myocardial perfusion imaging in magnetic resonance imaging. Mag. Res. Quart. 10:249-286, 1994.

Bassingthwaighte, J. B., and G. M. Raymond. Evaluating rescaled range analysis for time series. Ann. Biomed. Eng. 22:432-444, 1994.

Caldwell, J. H., G. V. Martin, G. M. Raymond, and J. B. Bassingthwaighte. Regional myocardial flow and capillary permeability-surface area products are nearly proportional. Am. J. Physiol. 267 ( Heart Circ. Physiol. 36):H654-H666, 1994.

Wilke, N., K. Kroll, H. Merkle, Y. Wang, Y. Ishibashi, Y. Xu, J. Zhang, M. Jerosch-Herold, A. Mühler, A. E. Stillman, J. B. Bassingthwaighte, R. Bache, and K. Ugurbil. Regional myocardial blood volume and flow: First-pass MR imaging with polylysine-Gd-DTPA. J. Magn. Res. Imaging 5:227-237, 1995.

Wang, C. Y., P. L. Liu, and J. B. Bassingthwaighte. Off-lattice Eden-C cluster growth model. J. Phys. A: Math. Gen. 28:2141-2147, 1995.

Bassingthwaighte, J. B., and G. M. Raymond. Evaluation of the dispersional analysis method for fractal time series. Ann. Biomed. Eng. 23:491-505, 1995.

Bassingthwaighte, J. B., and D. A. Beard. Fractal 15 O-water washout from the heart. Circ. Res. 77:1212-1221, 1995.

Stapleton, D. D., T. C. Moffett, D. G. Baskin, and J. B. Bassingthwaighte. Autoradiographic assessment of blood flow heterogeneity in the hamster heart. Microcirculation 2:277-282, 1995.

Deussen, A., and J. B. Bassingthwaighte. Modeling [ 15 O]oxygen tracer data for estimating oxygen consumption. Am. J. Physiol. 270 ( Heart Circ. Physiol. 39):H1115-H1130, 1996.

King, R. B., G. M. Raymond, and J. B. Bassingthwaighte. Modeling blood flow heterogeneity. Ann. Biomed. Eng. 24:352-372, 1996.

Kroll, K., N. Wilke, M. Jerosch-Herold, Y. Wang, Y. Zhang, R. J. Bache, and J. B. Bassingthwaighte. Modeling regional myocardial flows from residue functions of an intravascular indicator. Am. J. Physiol. 271 ( Heart Circ. Physiol. 40):H1643-H1655, 1996.

Bassingthwaighte, J. B., B. Winkler, and R. B. King. Potassium and thallium uptake in dog myocardium. J. Nucl. Med. 38:264-274, 1997.

Poulain, C. A., B. A. Finlayson, and J. B. Bassingthwaighte. Efficient numerical methods for nonlinear facilitated transport and exchange in a blood-tissue exchange unit. Ann. Biomed. Eng. 25:547-564, 1997.

Li, Z., T. Yipintsoi, and J. B. Bassingthwaighte. Nonlinear model for capillary-tissue oxygen transport and metabolism. Ann. Biomed. Eng. 25:604-619, 1997.

Wang, C. Y., and J. B. Bassingthwaighte. Biological Growth on a Surface. Math. Biosci. 142:91-106, 1997.

Cannon, M. J., D. B. Percival, D. C. Caccia, G. M. Raymond, and J. B. Bassingthwaighte. Evaluating scaled windowed variance methods for estimating the Hurst coefficient of time series. Physica A 241:606-626, 1997.

Caccia, D. C., D. B. Percival, M. J. Cannon, G. Raymond, and J. B. Bassingthwaighte. Analyzing exact fractal time series: evaluating dispersional analysis and rescaled range methods. Physica A 246:609-632, 1997.

Eke, A., P. Herman, J. B. Bassingthwaighte, G. M. Raymond, M. Cannon, I. Balla, and C. Ikrenyi. Temporal fluctuations in regional blood cell flux in the rat brain cortex is a fractal process. Oxygen Transport to Tissue 16, Adv. Med. Biol. 428:703-709, 1997.

Qian, H., G. M. Raymond, and J. B. Bassingthwaighte. On two-dimensional fractional Brownian motion and fractional Brownian random field. J. Phys. A: Math. Gen. 31:L527-L535, 1998.

Beard, D. A., and J. B. Bassingthwaighte. Power-law kinetics of tracer washout from physiological systems. Ann. Biomed. Eng. 26:775-779, 1998.

Bassingthwaighte, J. B., Z. Li, and H. Qian. Blood Flows and Metabolic Components of the Cardiome. Prog. Biophys. Mol. Biol. 69:445-461, 1998.

Bassingthwaighte, J. B., D. A. Beard, and R. B. King. Fractal regional myocardial blood flows: the anatomical basis. In: Fractals in Biology and Medicine. Vol II , edited by G. Losa, D. W. Merlini E. and T. Nonnenmacher. Basel: Birkhauser, 1998, pp. 114-127.

Raymond, G. M., and J. B. Bassingthwaighte. Deriving dispersional and scaled windowed variance analyses using the correlation function of discrete fractional Gaussian noise. Physica A 265:85-96, 1999.

Bassingthwaighte, J. B., and Z. Li. Heterogeneities in myocardial flow and metabolism: exacerbation with abnormal excitation. Am. J. Cardiol. 83:7H-12H, 1999.

Qian, H., G. M. Raymond, and J. B. Bassingthwaighte. Stochastic fractal behavior in concentration fluctuation and fluorescence correlation spectroscopy. Biophys. Chem. 80:1-5, 1999.

Schwartz, L. M., T. M. Bukowski, J. H. Revkin, and J. B. Bassingthwaighte. Cardiac endothelial transport and metabolism of adenosine and inosine. Am. J. Physiol. 277 ( Heart Circ. Physiol. 46):1241-1251, 1999.

Kendziorski, C. M., J. B. Bassingthwaighte, and P. J. Tonellato. Evaluating maximum likelihood estimation methods to determine the Hurst coefficient. Physica A 273:439-451, 1999.

Bassingthwaighte, J. B., and Z. Li. The Cardiome Project: An integrated view of cardiac metabolism and regional mechanical function. Adv. Exp. Med. Biol. 471:541-553, 1999.

Eke, A., P. Herman, J. B. Bassingthwaighte, G. M. Raymond, M. Cannon, I. Balla, and C. Ikrenyi. Fractal analysis of physiological time series. Eur. J. Physiol. 439:403-415, 2000.

Prinzen, F. W., and J. B. Bassingthwaighte. Blood flow distributions by microsphere deposition methods. Cardiovasc. Res. 45:13-21, 2000.

Beard, D. A., and J. B. Bassingthwaighte. Advection and diffusion of substances in biological tissues with complex vascular networks. Ann. Biomed. Eng. 28:253-268, 2000.

Barta, E., S. Sideman, and J. B. Bassingthwaighte. Facilitated diffusion and membrane permeation of fatty acid in albumin solutions. Ann. Biomed. Eng. 28:331-345, 2000.

Prinzen, F. W., and J. B. Bassingthwaighte. Blood flow distributions by microsphere deposition methods. Cardiovasc. Res. 45:13-21, 2000.

Qian, H., and J. B. Bassingthwaighte. A class of flow bifurcation models with lognormal distribution and fractal dispersion. J. Theor. Biol. 205:261-268, 2000.

Bassingthwaighte, J. B. Editorial: Back to fundamentals: Anatomy-based physiological bioengineering. Ann. Biomed. Eng. 28:701-703, 2000.

Beard, D. A., and J. B. Bassingthwaighte. The fractal nature of myocardial blood flow emerges from a whole-organ model of arterial network. J. Vasc. Res. 37:282-296, 2000.

Schwartz, L. M., T. R. Bukowski, J. D. Ploger, and J. B. Bassingthwaighte. Endothelial adenosine transporter characterization in perfused guinea pig hearts. Am. J. Physiol. Heart Circ. Physiol. 279:H1502-H1511, 2000.

Bassingthwaighte, J. B. Strategies for the Physiome Project. Ann. Biomed. Eng. 28:1043-1058, 2000.

Refereed Chapters in Books:

Bassingthwaighte, J. B. The role of circulatory transport in physiological control systems. Directory of the Alumni Assoc. of the Mayo Grad. School. 40:29-32, 1964.

Bassingthwaighte, J. B., T. J. Knopp, and J. B. Hazelrig. A concurrent flow model for capillary-tissue exchanges. In: Capillary Permeability (Alfred Benzon Symp. II) , edited by C. Crone and N. A. Lassen. Copenhagen: Munksgaard, 1970, pp. 60-80.

Yipintsoi, T., R. Tancredi, D. Richmond, and J. B. Bassingthwaighte. Myocardial extractions of sucrose, glucose, and potassium. In: Capillary Permeability (Alfred Benzon Symp. II) , edited by C. Crone and N. A. Lassen. Copenhagen: Munksgaard, 1970, pp. 153-156.

Bassingthwaighte, J. B., and T. Yipintsoi. The emergence function: Effects of flow and capillary-tissue exchange in the heart. In: Capillary Permeability (Alfred Benzon Symp. II) , edited by C. Crone and N. A. Lassen. Copenhagen: Munksgaard, 1970, pp. 239-252.

Bassingthwaighte, J. B., T. Strandell, and T. Yipintsoi. Flow limited washout of diffusible solutes from the heart. In: Capillary Permeability (Alfred Benzon Symp. II) , edited by C. Crone and N. A. Lassen. Copenhagen: Munksgaard, 1970, pp. 580-585.

Bassingthwaighte, J. B., F. P. Chinard, C. Crone, N. A. Lassen, and W. Perl. Definitions and terminology for indicator dilution methods. In: Capillary Permeability (Alfred Benzon Symp. II) , edited by C. Crone and N. A. Lassen. Copenhagen: Munksgaard, 1970, pp. 665-669.

Bassingthwaighte, J. B., and R. E. Sturm. Calibration of the Roentgen videodensitometer. In: Roentgen-, Cine-, and Videodensitometry: Fundamentals and applications for blood flow and heart volume determination , edited by P. H. Heintzen. Stuttgart, Germany: Georg Thieme Verlag, 1971, pp. 45-46.

Bassingthwaighte, J. B., and H. Reuter. Calcium movements and excitation-contraction coupling in cardiac cells. In: Electrical Phenomena in the Heart , edited by W. C. DeMello. New York: Academic Press, Inc., 1972, pp. 353-395.

Bassingthwaighte, J. B. The measurement of blood flows and volumes by indicator dilution. In: Medical Engineering , edited by C. D. Ray. Chicago: Yearbook Publishers, 1974, pp. 246-260.

Bassingthwaighte, J. B. Approaches to modeling radiocardiographic data: Comments on F. Castellana's modeling of the central circulation. In: Quantitative Nuclear Cardiography , edited by R. P. Pierson Jr., J. P. Kriss, R. H. Jones and W. J. MacIntyre. N.Y.: John Wiley & Sons, 1975, pp. 226-230.

Grabowski, E. F., and J. B. Bassingthwaighte. Capillary transport and exchange: An osmotic weight transient model for estimation of capillary transport parameters in myocardium. In: Microcirculation Vol. 2 (Proc. First World Cong. for the Microcirculation) , edited by J. Grayson and W. Zingg. New York: Plenum Publishing Corporation, 1976, pp. 29-50.

Davies, D. R., J. B. Bassingthwaighte, and P. J. Kelly. Blood flow and ion exchange in bone. In: Skeletal Research , edited by D. J. Simons and D. Kunins. N.Y.: Academic Press, Inc., 1979, pp. 397-419.

King, R. B., and J. B. Bassingthwaighte. Radioactivity. In: Data in Medicine , edited by R. S. Reneman and J. Strackee. The Hague, Netherlands: Martinus Nijhoff, 1979, pp. 79-113.

King, R. B., and J. B. Bassingthwaighte. Radiotracer techniques for measurement of tissue blood flow, volume, and transcapillary flux. In: Progress in Microcirculation Res. , edited by D. Garlick. Sydney, Australia: Committee in Postgraduate Med. Ed. U.N.S.W., 1981, pp. 429-439.

Bassingthwaighte, J. B., and B. Winkler. Kinetics of blood to cell uptake of radiotracers. In: Biological Transport of Radiotracers , edited by L. G. Columbetti: CRC Press, 1982, pp. 97-146.

Bassingthwaighte, J. B. Comments on radionuclide and NMR methods of evaluation. In: Clinical Diagnosis of Atherosclerosis: Quantitative Methods of Evaluation , edited by M. G. Bond, W. Insull Jr., S. Glagov, A. B. Chandler and J. F. Cornhill: Springer-Verlag, 1983, pp. 217-219.

Bassingthwaighte, J. B., and C. A. Goresky. Modeling in the analysis of solute and water exchange in the microvasculature. In: Handbook of Physiology. Sect. 2, The Cardiovascular System. Vol IV, The Microcirculation , edited by E. M. Renkin and C. C. Michel. Bethesda, MD: Am. Physiol. Soc., 1984, pp. 549-626.

Bassingthwaighte, J. B. Constraints in the interpretation of dynamic images of metabolic events. In: Simulation and Imaging of the Cardiac System , edited by S. Sideman and R. Beyar. Dordrecht: Martinus Nijhoff, 1985, pp. 378-390.

Bassingthwaighte, J. B., C. Y. Wang, M. Gorman, D. DeWitt, I. S. Chan, and H. V. Sparks. Endothelial regulation of agonist and metabolite concentrations in the interstitium. In: Carrier-Mediated Transport of Solutes from Blood to Tissue , edited by D. L. Yudilevich and G. E. Mann. New York: Longman, 1985, pp. 191-203.

Bassingthwaighte, J. B., I. S. Chan, and T. C. Moffett. Serotonin uptake during transcoronary passage. Prog. Appl. Microcirc. 10:12-20, 1986.

Bassingthwaighte, J. B. Transport of small molecules across the capillary wall: Assessment via multiple indicator dilution methods. In: Microcirculatory Technology , edited by C. H. Baker and W. L. Nastuk. Orlando, Florida: Academic Press, Harcourt Brace Jovanovich, 1986, pp. 447-470.

Bassingthwaighte, J. B. The myocardial cell. In: Cardiology: Fundamentals and Practice , edited by R. O. Brandenburg, V. Fuster, E. R. Giuliani and D. C. McGoon. Chicago: Year Book Medical Publishers, 1987, pp. 113-148.

Bassingthwaighte, J. B., L. Noodleman, R. T. Eakin, and R. B. King. Integrated phenomenology of transport, permeation, and metabolic reactions in the heart. In: Activation, Metabolism and Perfusion of the Heart. Simulation and Experimental Models , edited by S. Sideman and R. Beyar. Dordrecht: Martinus Nijhoff, 1987, pp. 621-642.

Wong, A. Y. K., A. Fabiato, and J. B. Bassingthwaighte. Model of Ca Release Mechanism from the Sarcoplasmic Reticulum: Ca-mediated Activation, Inactivation and Reactivation. In: Electromechanical Activation, Metabolism and Perfusion of the Heart. Simulation and Experimental Models , edited by S. Sideman and R. Beyar. Dordrecht: Martinus Nijhoff, 1987, pp. 281-295.

Bassingthwaighte, J. B. Myocardial microcirculatory exchange: the setting for cardiac positron tomographic imaging. In: Regional Myocardial Metabolism by Positron Tomography , edited by H. R. Schelbert, J. R. Neely, M. E. Phelps and H. W. Heiss. Mahwah, New Jersey: Foundation for Advances in Clinical Medicine, Inc., 1987, pp. 51-65.

Bassingthwaighte, J. B., R. B. King, J. E. Sambrook, and B. H. Van Steenwyk. Fractal analysis of blood-tissue exchange kinetics. In: Oxygen Transport to Tissue X, Adv. Exp. Med. Biol. 222 , edited by M. Mochizuki et al.. New York: Plenum Press, 1988, pp. 15-23.

Rose, C. P., C. A. Goresky, G. G. Bach, J. B. Bassingthwaighte, and S. E. Little. In vivo comparison of non-gaseous metabolite and oxygen transport in the heart. In: Oxygen Transport to Tissue X. Adv. Exp. Med. Biol. 222 , edited by M. Mochizuki et al.. New York: Plenum Press, 1988, pp. 45-54.

Catravas, J. D., J. B. Bassingthwaighte, and H. V. Sparks, Jr.. Adenosine transport and uptake by cardiac and pulmonary endothelial cells. Chapter 5. In: Endothelial Cells, Vol. I , edited by U. S. Ryan. Boca Raton, FL: CRC Press, 1988, pp. 65-84.

Bassingthwaighte, J. B., and R. B. King. Modeling the kinetics of exchange and transformation of positron labelled substrates. In: Medical Applications of Cyclotrons IV , edited by V. Nanto and E. Suolinna. Turku, Finland: Ann. Univ. Turkuensis D:27, 1988, pp. 41-55.

Bassingthwaighte, J. B., R. B. King, B. Van Steenwyk, and R. T. Eakin. Fractal approaches to myocardial flows. In: Analysis and simulation of the cardiac system - ischemia , edited by S. Sideman and R. Beyar. Boca Raton, FL: CRC Press, 1989, pp. 379-390.

van Beek, J. H. G. M., J. B. Bassingthwaighte, and S. A. Roger. Fractal networks explain regional myocardial flow heterogeneity. In: Oxygen Transport to Tissue XI. Adv. Exp. Med. Biol. 248 , edited by K. Rakusan. New York: Plenum Press, 1989, pp. 249-257.

Yamashiro, S. M., D. W. Slaaf, R. S. Reneman, G. J. Tangelder, and J. B. Bassingthwaighte. Fractal analysis of vasomotion. In: Mathematical Approaches to Cardiac Arrhythmias. Ann. N. Y. Acad. Sci. Vol.591 , edited by J. Jalife, 1990, pp. 410-416.

Bassingthwaighte, J. B., J. H. G. M. van Beek, and R. B. King. Fractal branchings: The basis of myocardial flow heterogeneities?. In: Mathematical Approaches to Cardiac Arrhythmias. Ann. N. Y. Acad. Sci. Vol.591 , edited by J. Jalife, 1990, pp. 392-401.

Bassingthwaighte, J. B. Microcirculatory considerations in NMR flow imaging. Magnetic Resonance in Medicine 14:172-178, 1990.

Bassingthwaighte, J. B., J. H. Caldwell, G. Raymond, K. Kroll, and G. V. Martin. Are flow, transport capacities, and metabolic requirements matched regionally in the myocardium?. In: Cardiac Electrophysiology, Circulation and Transport , edited by S. Sideman, R. Beyar and A. G. Kléber. Dordrecht: Kluwer Academic, 1991, pp. 281-293.

Bassingthwaighte, J. B. The myocardial cell. In: Cardiology: Fundamentals and Practice, 2nd Ed. , edited by E. R. Giuliani, V. Fuster, B. J. Gersh, M. D. McGoon and D. C. McGoon. St. Louis, MO: Mosby-Year Book Inc., 1991, pp. 113-149.

Bassingthwaighte, J. B., R. B. King, S. A. Roger, and J. H. G. M. van Beek. Heterogeneity or non-random inhomogeneities in structures and functions in the heart.. In: Image analysis and simulation of the cardiac system , edited by S. Sideman and R. Beyar. London: Freund Publishing House, 1991, pp. 383-396.

Bassingthwaighte, J. B. New tools: Fractal structures and dynamics in biology. BMES Bull. 15:21-26, 1991.

Bassingthwaighte, J. B. Chaos in the Fractal Arteriolar Network. In: The Resistance Vasculature , edited by J. A. Bevan, W. Halpern and M. J. Mulvany. Totowa, N.J.: Humana Press Inc., 1991, pp. 431-449.

Bassingthwaighte, J. B., R. B. King, and K. Kroll. A multisubstrate blood-tissue exchange model for the analysis of transients in cardiac tracer. In: Imaging in Transport Processes , edited by S. Sideman and K. Hijikata. New York: Begell House Inc. Publishers, 1993, pp. 493-508.

Bassingthwaighte, J. B., A. Deussen, R. P. Beyer, I. S. Chan, G. R. Raymond, R. B. King, T. R. Bukowski, J. D. Ploger, K. Kroll, J. Revenaugh, J. M. Link, and K. A. Krohn. Oxygen transport in the myocardium. In: Advances in Biological Heat and Mass Transfer HTD-Vol. 231 , edited by J. J. McGrath. New York: ASME, 1992, pp. 113-120.

Bassingthwaighte, J. B., G. R. Raymond, and J. I. S. Chan. Principles of tracer kinetics. In: Nuclear Cardiology: State of the Art and Future Directions , edited by B. L. Zaret and G. A. Beller. St. Louis: Mosby-Year Book, 1993, pp. 3-23.

Bassingthwaighte, J. B., J. R. Revenaugh, A. Deussen, M. M. Graham, T. K. Lewellen, J. M. Link, and K. A. Krohn. Evaluation of coronary perfusion by positron emission tomography. In: Recent Advances in Coronary Circulation , edited by Y. Maruyama, F. Kajiya, J. I. E. Hoffman and J. A. E. Spaan. Tokyo: Springer-Verlag, 1993, pp. 2-16.

Bassingthwaighte, J. B. Chapter 20. Chaos in cardiac signals. In: Interactive Phenomena in the Cardiac System , edited by S. Sideman and R. Beyar. New York: Plenum, 1993, pp. 207-218.

Bassingthwaighte, J. B. Toward modeling the human physionome. In: Molecular and Subcellular Cardiology: Effects on Structure and Function , edited by S. Sideman and R. Beyar. New York: Plenum, 1995, pp. 331-339.

Bassingthwaighte, J. B., D. A. Beard, D. B. Percival, and G. M. Raymond. Fractal structures and processes. In: Chaos and the Changing Nature of Science and Medicine: An Introduction , edited by D. E. Herbert. Woodbury, New York: AIP Press, 1996, pp. 54-79.

Bassingthwaighte, J. B. A design and strategy for the cardiome project. Chapter 28. In: Analytical and Quantitative Cardiology , edited by S. Sideman and R. Beyar. New York: Plenum, 1997, pp. 325-339.

Bassingthwaighte, J. B., C. A. Goresky, and J. H. Linehan. Ch. 1 Modeling in the analysis of the processes of uptake and metabolism in the whole organ. In: Whole organ approaches to cellular metabolism , edited by J. B. Bassingthwaighte, C. A. Goresky and J. H. Linehan. New York: Springer Verlag, 1998, pp. 3-27.

Bassingthwaighte, J. B., K. Kroll, L. M. Schwartz, G. M. Raymond, and R. B. King. Ch. 7. Strategies for uncovering the kinetics of nucleoside transport and metabolism in capillary endothelial cells. In: Whole Organ Approaches to Cellular Metabolism , edited by J. B. Bassingthwaighte, C. A. Goresky and J. H. Linehan. New York: Springer Verlag, 1998, pp. 163-188.

Kroll, K., and J. B. Bassingthwaighte. Ch. 11. Role of capillary endothelial cells in transport and metabolism of adenosine in the heart: an example of the impact of endothelial cells on measures of metabolism. In: Whole Organ Approaches to Cellular Metabolism , edited by J. B. Bassingthwaighte, C. A. Goresky and J. H. Linehan. New York: Springer Verlag, 1998, pp. 261-275.

Bassingthwaighte, J. B., D. A. Beard, Z. Li, and T. Yipintsoi. Is the fractal nature of intraorgan spatial flow distributions based on vascular network growth or local metabolic needs?. In: Vascular morphogenesis: In Vivo, In Vitro, In Mente , edited by C. D. Little, V. Mironov and E. H. Sage. Boston: Birkhauser, 1998, pp. 241-259.

Van der Vusse, G. J., J. F. C. Glatz, F. A. Van Nieuwenhoven, R. S. Reneman, and J. B. Bassingthwaighte. Transport of long-chain fatty acids across the muscular endothelium. In: Skeletal Muscle Metabolism in Exercise and Diabetes. Adv. Exp. Med. Biol. 441 , edited by E. A. Richter, H. Galbo, B. Kiens and B. Saltin. New York: Plenum Press, 1998, pp. 181-191.

Wang, C. Y., and J. B. Bassingthwaighte. Capillary domains. In: Applied Mechanics in the Americas Volume 6 , edited by P. B. Goncalves, I. Jasiuk, D. Pamplona, C. Steele, H. I. Weber and L. Bevilacqua.. Rio de Janeiro, Brazil: AAM and ABCM, 1999, pp. 39-42.