James B. Bassingthwaighte

EDUCATION

INSTITUTION AND LOCATION	DEGREE	YEAR (s)	FIELD OF STUDY
University of Toronto, Canada	B.A.	1951	Physiology & Biochemistry
University of Toronto Medical School	M.D.	1955
Postgraduate Medical School of London, England		1957-1958	Medicine
Mayo Graduate School of Medicine, Rochester, Minnesota		1958-1962	Cardiology
Mayo Graduate School of Medicine, Rochester, Minnesota	Ph.D.	1964	Physiology

Research and Professional Experience

• 1962-1964 Assistant to the Staff, Physiology, Mayo Foundation (E.H. Wood)
• 1967-1972 Assistant, then Associate Professor, Physiology, Mayo Graduate School of Medicine
• 1970-1971 Visiting Professor, Pharmacology Institute, University of Bern, Switzerland
• 1972-1975 Professor, Physiology and Medicine, Mayo Graduate School of Medicine
• 1975-1979 Director, Center for Bioengineering, University of Washington, Seattle, Washington
• 1975-present Professor, Bioengineering and Biomathematics, University of Washington, Seattle, Washington
• 1979-1981 Visiting Professor of Medicine and Physiology, McGill University, Montreal
• 1990-present Affiliate Professor, University of Maastricht, Maastricht, The Netherlands
• 1994 and 1996 Visiting Professor, Physiology, Free University, Amsterdam, The Netherlands
• 1981-present Director, National Simulation Resource Facility, Transport and Exchange, University of Washington
• 1999 Hustinx Chair, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands

Honors

• 1964 Mayo Alumni Research (Balfour) Award
• 1964-1974 Research Career Development Award (NHLBI)
• 1979 Louis and Artur Lucian Award, McGill University
• 1978-1986 USA National Committee for Internat. Union of Physiol. Sci. (I.U.P.S.) (Chair 1983-1986)
• 1986 Alza Award of the Biomedical Engineering Society
• 1986-1999 Chair, Commission on Bioengineering in Physiology of the International Union of Physiological Scientists
• 1993 Burlington Award for Outstanding Research in Engineering, University of Washington
• 1993-2000 Editor-in-Chief, Annals of Biomedical Engineering
• 1995 Landis Award (Microcirculatory Society)
• 1996 Oxford Lecturer (International Soc. of Magnetic Resonance in Medicine)
• 1999 Distinguished Service Award, Biomedical Engineering Society
• 2000 Elected to National Academy of Engineering, USA

Societies

American Heart Association, American Physiological Society (Cardiovascular Section Chair, 1996-7), Biomedical Engineering Society (President 1977-8; ABME Editor-in-Chief 1993-), Biophysical Society, Microcirculatory Society (President 1990-1), ISOTT, Eur. Soc. Microcirculation, AIMBE (founding member), Soc. Math. Biol.

Selected Publications (out of 22l refereed papers and 46 reviewed book chapters)

Bassingthwaighte, J. B. Blood flow and diffusion through mammalian organs. Science 167:1347-1353, 1970.

Bassingthwaighte, J. B., and H. Reuter. Calcium movements and excitation-contraction coupling in cardiac cells. In: Electrical Phenomena in the Heart , edited by W. C. DeMello. New York: Academic Press, Inc., 1972, pp. 353-395.

Bassingthwaighte, J. B., T. Yipintsoi, and R. B. Harvey. Microvasculature of the dog left ventricular myocardium. Microvasc. Res. 7:229-249, 1974.

Bassingthwaighte, J. B. A concurrent flow model for extraction during transcapillary passage. Circ. Res. 35:483-503, 1974.

Guller, B., T. Yipintsoi, A. L. Orvis, and J. B. Bassingthwaighte. Myocardial sodium extraction at varied coronary flows in the dog: Estimation of capillary permeability by residue and outflow detection. Circ. Res. 37:359-378, 1975.

Tancredi, R. G., T. Yipintsoi, and J. B. Bassingthwaighte. Capillary and cell wall permeability to potassium in isolated dog hearts. Am. J. Physiol. 229:537-544, 1975.

Bassingthwaighte, J. B. Physiology and theory of tracer washout techniques for the estimation of myocardial blood flow: Flow estimation from tracer washout. Prog. Cardiovasc. Dis. 20:165-189, 1977.

Safford, R. E., E. A. Bassingthwaighte, and J. B. Bassingthwaighte. Diffusion of water in cat ventricular myocardium. J. Gen. Physiol. 72:513-538, 1978.

Bassingthwaighte, J. B., T. Yipintsoi, and T. J. Knopp. Diffusional arteriovenous shunting in the heart. Microvasc. Res. 28:233-253, 1984.

Bassingthwaighte, J. B., and C. A. Goresky. Modeling in the analysis of solute and water exchange in the microvasculature. In: Handbook of Physiology. Sect. 2, The Cardiovascular System. Vol IV, The Microcirculation , edited by E. M. Renkin and C. C. Michel. Bethesda, MD: Am. Physiol. Soc., 1984, pp. 549-626.

Bassingthwaighte, J. B., J. T. Kuikka, I. S. Chan, T. Arts, and R. S. Reneman. A comparison of ascorbate and glucose transport in the heart. Am. J. Physiol. 249 ( Heart Circ. Physiol. 18):H141-H149, 1985.

King, R. B., J. B. Bassingthwaighte, J. R. S. Hales, and L. B. Rowell. Stability of heterogeneity of myocardial blood flow in normal awake baboons. Circ. Res. 57:285-295, 1985.

Kuikka, J., M. Levin, and J. B. Bassingthwaighte. Multiple tracer dilution estimates of D- and 2-deoxy-D-glucose uptake by the heart. Am. J. Physiol. 250 ( Heart Circ. Physiol. 19):H29-H42, 1986.

Gorman, M. W., J. B. Bassingthwaighte, R. A. Olsson, and H. V. Sparks. Endothelial cell uptake of adenosine in canine skeletal muscle. Am. J. Physiol. 250 ( Heart Circ. Physiol. 19):H482-H489, 1986.

Bassingthwaighte, J. B., F. P. Chinard, C. Crone, C. A. Goresky, N. A. Lassen, R. S. Reneman, and K. L. Zierler. Terminology for mass transport and exchange. Am. J. Physiol. 250 ( Heart Circ. Physiol. 19):H539-H545, 1986.

Bassingthwaighte, J. B., M. A. Malone, T. C. Moffett, R. B. King, S. E. Little, J. M. Link, and K. A. Krohn. Validity of microsphere depositions for regional myocardial flows. Am. J. Physiol. 253 ( Heart Circ. Physiol. 22):H184-H193, 1987.

Bassingthwaighte, J. B., C. Y. Wang, and I. S. Chan. Blood-tissue exchange via transport and transformation by endothelial cells. Circ. Res. 65:997-1020, 1989.

Wangler, R. D., M. W. Gorman, C. Y. Wang, D. F. DeWitt, I. S. Chan, J. B. Bassingthwaighte, H. V. Sparks. Transcapillary adenosine transport and interstitial adenosine concentration in guinea pig hearts. Am. J. Physiol. 257 ( Heart Circ. 26):H89-H106, 1989.

Van Beek, J. H. G. M., S. A. Roger, and J. B. Bassingthwaighte. Regional myocardial flow heterogeneity explained with fractal networks. Am. J. Physiol. 257 ( Heart Circ. Physiol. 26):H1670-H1680, 1989.

Bassingthwaighte, J. B., M. A. Malone, T. C. Moffett, R. B. King, I. S. Chan, J. M. Link, and K. A. Krohn. Molecular and particulate depositions for regional myocardial flows in sheep. Circ. Res. 66:1328-1344, 1990.

Gonzalez, F., and J. B. Bassingthwaighte. Heterogeneities in regional volumes of distribution and flows in the rabbit heart. Am. J. Physiol. 258 ( Heart Circ. Physiol. 27):H1012-H1024, 1990.

Bassingthwaighte, J. B. Fractal vascular growth patterns. Acta Stereol. 11 (Suppl. 1):305-319, 1992.

Bassingthwaighte, J. B., I. S. Chan, and C. Y. Wang. Computationally efficient algorithms for capillary convection-permeation-diffusion models for blood-tissue exchange. Ann. Biomed. Eng. 20:687-725, 1992.

Caldwell, J. H., G. V. Martin, G. M. Raymond, and J. B. Bassingthwaighte. Regional myocardial flow and capillary permeability-surface area products are nearly proportional. Am. J. Physiol. 267 ( Heart Circ. Physiol. 36):H654-H666, 1994.

Bassingthwaighte, J. B., L. S. Liebovitch, and B. J. West. Fractal Physiology . New York, London: Oxford University Press, 1994, 399 pp.

Wilke, N., M. Jerosch-Herold, A. E. Stillman, K. Kroll, N. Tsekos, H. Merkle, T. Parrish, X. Hu, Y. Wang, J. Bassingthwaighte, R. J. Bache, K. Ugurbil. Concepts of myocardial perfusion imaging in magnetic resonance imaging. Mag. Res. Quart. 10:249-286, 1994.

Bassingthwaighte, J. B. Toward modeling the human physionome. In: Molecular and Subcellular Cardiology: Effects on Structure and Function , edited by S. Sideman and R. Beyar. New York: Plenum, 1995, pp. 331-339.

Bassingthwaighte, J. B., and D. A. Beard. Fractal 15 O-water washout from the heart. Circ. Res. 77:1212-1221, 1995.

King, R. B., G. M. Raymond, and J. B. Bassingthwaighte. Modeling blood flow heterogeneity. Ann. Biomed. Eng. 24:352-372, 1996.

Kroll, K., N. Wilke, M. Jerosch-Herold, Y. Wang, Y. Zhang, R. J. Bache, and J. B. Bassingthwaighte. Modeling regional myocardial flows from residue functions of an intravascular indicator. Am. J. Physiol. 271 ( Heart Circ. Physiol. 40):H1643-H1655, 1996.

Bassingthwaighte, J. B., B. Winkler, and R. B. King. Potassium and thallium uptake in dog myocardium. J. Nucl. Med. 38:264-274, 1997.

Li, Z., T. Yipintsoi, and J. B. Bassingthwaighte. Nonlinear model for capillary-tissue oxygen transport and metabolism. Ann. Biomed. Eng. 25:604-619, 1997.

Bassingthwaighte, J. B., C. A. Goresky, and J. H. Linehan, Editors. Whole organ approaches to cellular metabolism. Capillary permeation, cellular uptake and product formation. . New York: Springer Verlag, 1998, 575 pp.

Bassingthwaighte, J. B., Z. Li, and H. Qian. Blood Flows and Metabolic Components of the Cardiome. Prog. Biophys. Mol. Biol. 69:445-461, 1998.

Bassingthwaighte, J. B., and Z. Li. Heterogeneities in myocardial flow and metabolism: exacerbation with abnormal excitation. Am. J. Cardiol. 83:7H-12H, 1999.

Schwartz, L. M., T. M. Bukowski, J. H. Revkin, and J. B. Bassingthwaighte. Cardiac endothelial transport and metabolism of adenosine and inosine. Am. J. Physiol. 277 ( Heart Circ. Physiol. 46):1241-1251, 1999.

Bassingthwaighte, J. B., and Z. Li. The Cardiome Project: An integrated view of cardiac metabolism and regional mechanical function. Adv. Exp. Med. Biol. 471:541-553, 1999.

Kendziorski, C. M., J. B. Bassingthwaighte, and P. J. Tonellato. Evaluating maximum likelihood estimation methods to determine the Hurst coefficient. Physica A 273:439-451, 1999.

Eke, A., P. Herman, J. B. Bassingthwaighte, G. M. Raymond, M. Cannon, I. Balla, and C. Ikrenyi. Fractal analysis of physiological time series. Eur. J. Physiol. 439:403-415, 2000.

Prinzen, F. W., J. B. Bassingthwaighte. Blood flow distributions by microsphere deposition methods. Cardiovasc. Res. 45:13-21, 2000.

Barta, E., S. Sideman, and J. B. Bassingthwaighte. Facilitated diffusion and membrane permeation of fatty acid in albumin solutions. Ann. Biomed. Eng. 28:331-345, 2000.

Beard, D., J. B. Bassingthwaighte. Advection and diffusion of substances in biological tissues with complex vascular networks. Ann. Biomed. Eng. 28:253-268, 2000.