Lung Tutorial

Mechanics

OneAlvLung	One Alveolus Lung
Lung_RC	Lung modeled analogously as electrical RC circuit
Lung_RC_Air	Lung with Concentration and non-linear compliance
2CompLung_Air	Two compartment lung with concentrations and nonlinear compliances
Lutchen	This model is based on Lutchen et al. A nonlinear model combining pulmonary mechanics and gas concentration dynamics. IEEE Trans. Biomed. Eng. 29: 629-641, 1982.
BronchiBronchiolAlv	This model represents airway with a bronchi,a bronchioles, and a alveoli.
Surfactant	Surfactant effect on single bubble dynamics.
BronchTwoAlv	This model represents a bifurcating bronchiole with two alveolar compartments.
BronchTwoAlveoli_Surf
Bronch_OneAlv_Gas	Airways are modeled by two elastic tanks, flow resistance, and inlet concentration that depends on flow direction.
Four_Comp	This model represents a rigid airway, compliant bronchiole, compliant bronchiolus and a compliant alveolus.
Bif_Airway	This model represents a bifurcating compliant airway that could be used as a building block for constructing a network of airway. You could use the model to simulate flow in rigid airway bifurcation.
Bif_Bronch	This model represents a bifurcating compliant bronchiole that could be used as a building block for constructing a network of bronchi.
Weibel_R_4Gen	This model represents four generations of the bipodial human lung. The lengths and diameter of the airways are based on the weibel model.
Weibel_RC_4Gen	This model represents four generations of the bipodial human lung with compliant airways. The lengths and diameter of the airways are based on the weibel model.
Norm Ventiln
Vital Capac
Airway Obstr
Alv Collapse
PleuralPress	Two different ways of expressing breathing, one as if using a ventilator at the mouth and the other one as human pleural muscle generating pressure gradient against external pressure.
FEV
Pneumo thorax
Athanasiades_00_3Air	This model is based on Athanasiades et al. energy analysis of a nonlinear model of the normal human lung. J Biol Sys. 8(2):115-39, 2000.
LungExch_O2_CO2	Distributed model for O2-CO2 transport and exchange between a three compartment lung and the pulmonary circulation, modeled as a blood tissue exchange (BTEX) unit.

VentilControl

Ventil_CObreathing	A mathematical model of ventilation response to inhaled carbon monoxide, based on the work of James H. Stuhmiller and Louise M. Stuhmiller [2005, Journal of Applied Physiology, 98, 2033-2044] and developed by Raymond Yakura as a final project for BIOEN 589, University of Washington.
Chemoreceptor
CO2_Breathing
Duffin_Chemorec

Alv-CapExch

TwoTankExch_
AlvCapGradients_
Hlastala72	Periodic airway transport and alveolus-capillary gas exchange.
GasExchLu_01	Model for O2, CO2, and N2 in airways and O2, CO2 in blood of circulating system.
GasExch4Tank

CapTissExch

Comp2Flow	Stirred tank model for exchange between plasma, and ISF with an external input function, Cin.
Comp2Buff
BTEX20	This is a model of a “tissue cylinder” consisting of a capillary plasma region and an interstitial fluid (isf) region. The model is multi-segmented to solve the convection diffusion equation. It is modeled as a pair of coupled partial differential equations.
CTEX20	N well stirred tanks (i.e. compartmental models with flow) representing the capillary region are connected in series and exchange with N additional tanks in parallel representing the interstitial fluid region.
Sanshe	Sangren -Sheppard (1953) Model for exchange of substance between a liquid flowing in a vessel and an external compartment
BTEX30	This is a model of a “tissue cylinder” consisting of a capillary plasma region, an interstitial fluid region, and a cellular region. The model is multi-segmented to solve the convection diffusion equation. This model contains three partial differential equations.
BTEX40	This is a model of a “tissue cylinder” consisting of a capillary plasma region, an interstitial fluid region, endothelial cell, and parenchymal cell. The model is multi-segmented to solve the convection diffusion equation. This model is a set of four coupled partial differential equation.

HbO2Dash06	Simultaneous Blood-Tissue Exchange of Oxygen, Carbon Dioxide, Bicarbonate and Hydrogen Ion
GENTEX	GENTEX is a GENeric Tissue EXchange model characterizing the flow and transformation of metabolites. GENTEX is a whole organ model of the vascular network providing intraorgan flow heterogeneity and accounts for substrate transmembrane transport, binding, and metabolism in erythrocytes, plasma, endothelial cells, interstitial space, and cardiomyocytes.

RBC_plasma_exch_O2_CO2

Gas Buffers

MbO2	Model for single site first order binding, e.g. O2 to myoglobin.
HbO2Hill	Oxygen Saturation Curve using Hill’s Equation.
HbO2Adair	Hemoglobin O2 binding polynomial function of pO2.
BloodO2	Hemoglobin Bound plus Dissolved O2 in Blood with pO2.
Hbindep	Model for slow ligand binding to 4 independent identical sites.
HbCoop	Oxyhemoglobin binding to 4 interdependent cooperative sites.
HbCO2	Carbamino hemoglobin (HbCO2) dissociation at chosen pO2, pH.
HbO2Co2H	Model for O2 binding to hemoglobin at varied pCO2 and pH.
Exchange_O2_CO2_HCO3_and_H	BTEX with O2, CO2, HCO3, and H exchange.
HbO2 Severinghaus	Simple.Severinghaus

AirwayWallExch

Kumagai00	Simple compartmental model including soluble gas transport in the alveoli, transfer between the bronchial circulation and the conducting airways, and metabolism.
Ethanol_Anderson
Bronch_CapExch

Air-BodyExch

Styrene_Inhal	Inhalation pharmacokinetics of styrene in rats and humans based on the work of J.C. Ramsey and M.E. Andersen (1984)
GasExch4Tank	Recirculation of O2 and CO2 between a 2-compartment lung and 2-compartment body.
CVResp