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Cardiac Physiome Society workshop: November 6-9, 2017 , Toronto

Kumagai_2000

Simple compartmental model including soluble gas transport in the alveoli, transfer between the bronchial circulation and the conducting airways, and metabolism.

Model number: 0194

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Description

  This is a simple model of the pulmonary system where the lung is subdivided into 
  compartments representing air spaces: dead space, peripheral bronchial tract, and 
  the alveolar space; blood volumes: upper airway mucus, pulmonary capillary, systemic 
  blood flow; and tissue space: whole body excluding the lungs. The upper airway mucus 
  layer resides along the peripheral bronchial tract and has a continuous blood flow 
  QM which effectively communicates with the gas in the bronchial tract. 	


Equations

  • Ventilation

    The alveolar compartment changes volume with ventilation. Prior to steady state, the lung undergoes tidal breathing, represented by a sinusoid



    After a pre-determined number of breaths, a secondary maneuver is performed: prolonged exhale or rebreathing. For a prolonged exhalation maneuver, the lungs are brought quickly to total lung capacity (TLC), then drained at a constant rate to the residual volume (RV).

    "

    In a rebreathing maneuver, an external bag is attached and the subjects breaths a number of breaths, generally 8, directly into and out of a bag.



Compartmental Definitions The following compartments use conservation of mass equations to follow the concentration of the soluble gas tracer.
  • Dead Space



  • Peripheral Bronchial Compartment

  • Alveolar Compartment




  • Body Compartment




  • Rebreathing Bag


Download JSim model project file

References

  Kumagai S, and Matsunaga I. A lung model describing uptake of organic solvents and 
  roles of mucosal blood flow and metabolism in the bronchioles. Inhal Toxicol 12: 491-510, 2000. 	

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Key Terms

solvent, water-soluble, partition coefficient, blood-soluble, compartment, pharmacokinetic, uptake, Publication, Respiratory system, Air-blood gas exchange, Data

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Posted by: BEJ

Acknowledgements

Please cite www.physiome.org in any publication for which this software is used and send an email with the citation and, if possible, a PDF file of the paper to: staff@physiome.org.
Or send a copy to:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 02Nov16, 2:35 pm.]

Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.