Models a tissue cylinder consisting of five regions: plasma, interstitial fluid,endothelial cells, parenchymal cells, and mitochondria.
Model number: 0083
Further reading: Distributed Blood Tissue Exchange Models Explained Download PDF file.
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These partial differential equations model a "tissue cylinder" consisting of five regions. The five regions are capillary plasma, p; endothelial cell, ec; interstitial fluid, isf; parenchymal cell, pc; and mitochondria, mito; and are separated by four barriers--the luminal or plasma surface and endothelial cell layer; the albuminal surface of the endothelial cell facing the interstitium; the membrane between the interstitial fluid and parenchymal cell; and the membrane between the parenchymal cell and the mitochondria. In addition, there is a diffusional path from plasma to ISF bypassing endothelial cells via intercellular clefts.