Models a tissue cylinder consisting of two regions: plasma and interstitial fluid. Model augmented with additional calculations.
Model number: 0225
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These partial differential equations model a "tissue cylinder" consisting of two regions. The two regions are capillary plasma, p; and interstitial fluid, isf; there is a diffusional path from plasma to the isf.
This BTEX20 model has been augmented with a visual interface.
This BTEX20 model has been augmented with a MML procedure written in Java to calculate statistics on input and output concentration flow curves.
This BTEX20 model has been augmented with the calculations for the Terminology paper (J.B. Bassingthwaighte, et al., 1986).
This BTEX20 model has been augmented with a comparable two compartment model in order to show that setting the axial diffusion coefficients to large (and unrealistic values) converts a distributed model into a compartmental model.
Left Boundary Conditions
Right Boundary Conditions
The equations for this model may also be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
W.C. Sangren and C.W. Sheppard. A mathematical derivation of the exchange of a labelled substance between a liquid flowing in a vessel and an external compartment. Bull Math BioPhys, 15, 387-394, 1953. C.A. Goresky, W.H. Ziegler, and G.G. Bach. Capillary exchange modeling: Barrier-limited and flow-limited distribution. Circ Res 27: 739-764, 1970. J.B. Bassingthwaighte. A concurrent flow model for extraction during transcapillary passage. Circ Res 35:483-503, 1974. B. Guller, T. Yipintsoi, A.L. Orvis, and J.B. Bassingthwaighte. Myocardial sodium extraction at varied coronary flows in the dog: Estimation of capillary permeability by residue and outflow detection. Circ Res 37: 359-378, 1975. C.P. Rose, C.A. Goresky, and G.G. Bach. The capillary and sarcolemmal barriers in the heart--an exploration of labelled water permeability. Circ Res 41: 515, 1977. J.B. Bassingthwaighte, F.P. Chinard, C. Crone, C.A. Goresky, N.A. Lassen, R.S. Reneman, and K.L. Zierler. Terminology for mass transport and exchange. Am. J. Physiol. 250 (Heart. Circ. Physiol. 19): H539-H545, 1986. J.B. Bassingthwaighte, C.Y. Wang, and I.S. Chan. Blood-tissue exchange via transport and transformation by endothelial cells. Circ. Res. 65:997-1020, 1989. Poulain CA, Finlayson BA, Bassingthwaighte JB.,Efficient numerical methods for nonlinear-facilitated transport and exchange in a blood-tissue exchange unit, Ann Biomed Eng. 1997 May-Jun;25(3):547-64.
Blood Tissue Exchange (BTEX) models
- BTEX10 : Single region (Capillary) model,
- BTEX10 model with Terminology plots,
- BTEX10stat : BTEX10 with inflow and outflow concentration statistics,
- BTEX10x2CircularFlow : Two BTEX10s used as a pipes for circular flow illustrating right and left flows,
- BTEX10_OscillatingFlow : BTEX10 used as a pipe for oscillating flow,
- BTEX20 : Two region (Capillary and ISF) model,
- BTEX20_Augmented : BTEX20 with visual interface and additional calculations,
- NestedPlots : BTEX20 used to illustrate "Nested Plots",
- DiffusionLimitedProfiles : BTEX20 with radial diffusion in parenchymal cell: A 2-d PDE in (x,r,t) ,
- BTEX20radialDiffusion : BTEX20 with radial diffusion in parenchymal cell: A 2-d PDE in (x,r,t) with Java interface to Matlab(TM) ,
- How the Modular Program Constructor (MPC) tool generated the BTEX20radialDiffusion model (contains documentation and code for MPC)
- BTEX30 : Three region (Capillary, ISF, and parenchymal cell) model,
- BTEX40 : Four region (Capillary, endothelial cell, ISF, and parenchymal cell) model,
- BTEX40_Augmented : BTEX40 with visual interface,
- BTEX50 : Five region (Capillary, endothelial cell, ISF, parenchymal cell, and mitochondria)) model,
- MID4pde : Multiple indicator dilution model for vascular (BTEX10), extravascular (BTEX20) and permeant (BTEX40) tracers,
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Please cite www.physiome.org in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
[This page was last modified 14Mar18, 3:17 pm.]
Model development and archiving support at physiome.org provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.