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BTEX10_OscillatingFlow

Two single compartments use an oscillating flow through a pipe (BTEX10) to exchange material and volume.

Model number: 0308

Further reading:     Distributed Blood Tissue Exchange Models Explained Download PDF file.

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Description


This model consists of two well-stirred (instantaneously mixed) compartments connected by a pipe (BTEX10) through which they exchange material and volume by an oscillating flow. The solutions from BTEX10_OscillatingFlow are compared with Comp1_OscillatingFlow (2nd model in this project, where the BTEX10 pipe is replace by a one compartment pipe) by setting the diffusion cofficient to a large value (D=0.1 cm^2/sec).

Equations

 

     Algebraic Equations



 

     Differential Equations






    Left Boundary Conditions


    Right Boundary Conditions


     Initial Conditions

,   ,   ,   ,   and     or  

where F is the oscillating flow, A1 and A2 are the amounts of substrate in volumes V1 and V2 respectively, and Cm is the concentration in the pipe with volume Vm and length L.

The equations for this model may also be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

Download JSim project file

References


W.C. Sangren and C.W. Sheppard.  A mathematical derivation of the
exchange of a labelled substance between a liquid flowing in a
vessel and an external compartment.  Bull Math BioPhys, 15, 387-394,
1953.

C.A. Goresky, W.H. Ziegler, and G.G. Bach. Capillary exchange modeling:  
Barrier-limited and flow-limited distribution. Circ Res 27: 739-764, 1970.

J.B. Bassingthwaighte. A concurrent flow model for extraction
during transcapillary passage.  Circ Res 35:483-503, 1974.

B. Guller, T. Yipintsoi, A.L. Orvis, and J.B. Bassingthwaighte. Myocardial 
sodium extraction at varied coronary flows in the dog: Estimation of 
capillary permeability by residue and outflow detection. Circ Res 37: 359-378, 1975.

C.P. Rose, C.A. Goresky, and G.G. Bach.  The capillary and
sarcolemmal barriers in the heart--an exploration of labelled water
permeability.  Circ Res 41: 515, 1977.

J.B. Bassingthwaighte, F.P. Chinard, C. Crone, C.A. Goresky,
N.A. Lassen, R.S. Reneman, and K.L. Zierler.  Terminology for
mass transport and exchange.  Am. J. Physiol. 250 (Heart. Circ.
Physiol. 19): H539-H545, 1986.

J.B. Bassingthwaighte, C.Y. Wang, and I.S. Chan.  Blood-tissue
exchange via transport and transformation by endothelial cells.
Circ. Res. 65:997-1020, 1989.

Poulain CA, Finlayson BA, Bassingthwaighte JB.,Efficient numerical methods 
for nonlinear-facilitated transport and exchange in a blood-tissue exchange 
unit, Ann Biomed Eng. 1997 May-Jun;25(3):547-64. 

Related Models

Blood Tissue Exchange (BTEX) models

Key Terms

BTEX10, Oscillating flow, reversing flow, PDE, advection, diffusion

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Model History

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Acknowledgements

Please cite www.physiome.org in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 14Mar18, 3:17 pm.]

Model development and archiving support at physiome.org provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.