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National Simulation Resource

Online Demonstrations

Requirements for Running XSIM Online Demonstrations

XSIM is a X-Windows program, so you need an X server running on your local machine. X servers are standard on most UNIX/LINUX systems. Windows and Macintosh users need to install their own X server. The X server must be running and set to accept application displays from NSR before you can run the models over the web. For example, UNIX users could use the xhost command in their local terminal window:

xhost +nsr.bioeng.washington.edu

Once you have a running X-server that will host X application displays from NSR, you can launch XSIM by clicking on a hyperlink to a model parameter file (by convention, these are files ending in the suffix .par). For more information, please read the FAQ on how to use online demos.

XSIM Interface Tour

We have provided a tutorial and tour through XSIM that demonstrates many of its capabilities (video clips are provided for MS Windows users; an X server is not required.

Blood-Tissue Exchange Models

Single-element models

simpipe
Flow through a pipe.
micmen
A simple model for Michaelis-Menten reaction.
enzmem
Two enzymes in vesicle.
FacTransport
A set of nonlinear transmembrane transporters (tutorial available).

Single capillary-tissue unit

comp2ode
A two-compartment blood-tissue exchange model.
btex20
A two-region, distributed blood-tissue exchange model.
btex40
A four-region, distributed blood-tissue exchange model.

Whole-organ models

mmid4
A multi-path, multi-indicator, four-region organ model (tutorial available).
msid4
A multi-path, multi-species, four-region organ model.
gentex
A multi-path, multi-species, five-region organ model with nonlinear transmembrane transport, nonlinear reactions and time-varying blood flow and volume (tutorial available).
compos
A model of coupled solute-solvent exchange between two compartments.
osmotic
A model of solute and water fluxes in a whole organ.

Whole-body models

simvol
Multi-organ recirculating system with shunt.
body
A whole-body recirculation model.

Cellular Models

Action potential models

hodhux
Hodgkin-Huxley model for membrane conductance.
MLRd
Modified Luo-Rudy dynamic model of the guinea pig cardiac ventricular action potential in a single cell.
ito1
An ion channel model recently developed by J. L. Greenstein to study the "Role of the Calcium-Independent Transient Outward Current Ito1 in Shaping Action-Potential Morphology and Duration" (Circ Res. 87:1026-1033, 2000).
wrj3
Action potential model for canine ventricular cell (Winslow-Rice-Jafri model version 3) that incoporated the above Ito1 model developed by J. L. Greenstein el al.
jbAP
Modification of wrj3 by A. Michailova and A. D. McCulloch.

Metabolic models

Demo Models

demo
Decaying sine, cosine, and tangent waves.
BTEX
A demo to illustrate the theory and method of the axially-distributed blood-tissue exchange model (video clips for MS Windows users).

Last modified 20Dec04, 11:22 am.